生物活性

• 描述Moxifloxacin is a safe and effective antimicrobial that will be useful for treating acute sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. In clinical trials, moxifloxacin had clinical success rates of 88-97% and bacteriologic eradication rates of 90-97%^[1]. The median MIC of moxifloxacin for a large collection of L. monocytogenes strains of various origins (human, food, and environment) was 0.5 microg/ml (MIC range, 0.064 to 1 microg/ml). Both moxifloxacin and amoxicillin were bactericidal in broth against extracellular forms of L. monocytogenes^[3]. Moxifloxacin (MDA) possibly stimulates lipid peroxidation and enhances phagocytosis, as indicated by MDA production and survival prolongation, without being toxic, as indicated by WBC count. Therefore, under the appropriate conditions, moxifloxacin has a place in treatment of infections in immunosuppressed patients and of infections caused by S. maltophilia^[4].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02531438	Bacterial Pneumonia ... more >> Community-Acquired Infections Collapse <<	Phase 3	Completed	-	-
  NCT01406262	Diabetes Mellitus, Type 2	Phase 1	Completed	-	-
  NCT00575380	Bacterial Infections ... more >> Eye Infections Cataract Extraction Collapse <<	Phase 4	Completed	-	United States, Arizona ... more >> Cornea Consultants of Arizone Phoenix, Arizona, United States, 85032 United States, Arkansas Eye Care Arkansas Little Rock, Arkansas, United States, 72205 United States, California North Valley Eye Medical Group Mission Hills, California, United States, 91345 United States, Florida Center for Excellence in Eye Care Miami, Florida, United States, 33176 Eye Center of North Florida Panama City, Florida, United States, 32405 United States, Georgia Coastal Research Associates, LLC Atlanta, Georgia, United States, 30339 United States, Kentucky Kentuckiana Institute for Eye Research Louisville, Kentucky, United States, 40207 United States, Missouri Ophthalmology Associates St. Louis, Missouri, United States, 63131 United States, New York Ophthalmic Consultants of Long Island Rockville Centre, New York, United States, 11563 United States, Pennsylvania Eye Care Specialists Kingston, Pennsylvania, United States, 18704 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29464 Glaucoma Consultants and Center for Eye Research Mount Pleasant, South Carolina, United States, 29464 United States, Texas Corona Research Consultants El Paso, Texas, United States, 79904 Collapse <<

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• 参考文献

• [1] Culley CM, Lacy MK, Klutman N, Edwards B. Moxifloxacin: clinical efficacy and safety. Am J Health Syst Pharm. 2001;58(5):379–388

  [2] Balfour JA, Lamb HM. Moxifloxacin: a review of its clinical potential in the management of community-acquired respiratory tract infections. Drugs, 2000. 59(1): p. 115-39.

  [3] Grayo S, Join-Lambert O, Desroches MC, Le Monnier A. Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. Antimicrob Agents Chemother. 2008;52(5):1697–1702

  [4] Ioannidis O, Papaziogas B, Tsiaousis P, Paraskevas G, Giamarellos-Bourboulis EJ, Koutelidakis I. Effect of moxifloxacin on survival, lipid peroxidation and inflammation in immunosuppressed rats with soft tissue infection caused by Stenotrophomonas maltophilia. Microbiol Immunol. 2014;58(2):96–102